Increased Expression of TGF-β1 by 4-hexylresorcinol Is Mediated by Endoplasmic Reticulum and Mitochondrial Stress in Human Umbilical Endothelial Vein Cells
نویسندگان
چکیده
In our previous study, 4-hexylresorcinol (4HR) increased the expression level of vascular endothelial growth factor in human umbilical vein cells (HUVECs) via transforming factor-β1 (TGF-β1)-mediated pathway. Endoplasmic reticulum (ER) and mitochondrial stress is a positive regulator cellular differentiation. As TGF-β1 master for differentiation, 4HR treatment may increase ER stress. this HUVECs were treated using (1–100 μM) 24 h. The stress-associated markers Increased by administration was alleviated tauroursodeoxycholate (ER inhibitor) treatment. Combining these activities with elevated acetylation histone 3 (H3) treatment, HUVECs. Overall, through upregulation response as well H3
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2021
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app11199128